Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tipranavir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 1/20 | 0.99 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.99 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.99 |
| ▸ | PGR | P06401 | 1/20 | 0.99 |
| ▸ | CTSD | P07339 | 1/20 | 0.99 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.99 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.99 |
| ▸ | PGA5 | P0DJD9 | 1/20 | 0.99 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.99 |
| ▸ | CTSE | P14091 | 1/20 | 0.99 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.99 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.99 |
| ▸ | DRD1 | P21728 | 1/20 | 0.99 |
| ▸ | HTR2A | P28223 | 1/20 | 0.99 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.99 |
| ▸ | CCKAR | P32238 | 1/20 | 0.99 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.99 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.99 |
| ▸ | PPARG | P37231 | 1/20 | 0.99 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tipranavir SCHEMBL6953675 | 0.99 | MLNR (1.00) | MLNRNR1I2ABCB11PGRCTSD | |
| Tipranavir SCHEMBL13536854 | 0.99 | MLNR (1.00) | MLNRNR1I2ABCB11PGRCTSD | |
| Tipranavir SCHEMBL40629 | 0.99 | MLNR (1.00) | MLNRNR1I2ABCB11PGRCTSD | |
| Tipranavir SCHEMBL5414762 | 0.99 | MLNR (1.00) | MLNRNR1I2ABCB11PGRCTSD | |
| Tipranavir SCHEMBL6957763 | 0.99 | MLNR (1.00) | MLNRNR1I2ABCB11PGRCTSD | |
| Tipranavir SCHEMBL7407890 | 0.99 | MLNR (1.00) | MLNRNR1I2ABCB11PGRCTSD | |
| Tipranavir SCHEMBL29393318 | 0.99 | MLNR (1.00) | MLNRNR1I2ABCB11PGRCTSD | |
| SCHEMBL7398499 | 0.97 | MLNR (0.96) | MLNRNR1I2ABCB11PGRCTSD | |
| SCHEMBL7398500 | 0.97 | MLNR (0.96) | MLNRNR1I2ABCB11PGRCTSD | |
| SCHEMBL7401866 | 0.97 | MLNR (0.96) | MLNRNR1I2ABCB11PGRCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050042291-A1 | Diffusion layer modulated solids | HAWLEY MICHAEL (US) | 2005-02-24 | — | — | US | claimed |
| WO-2012010617-A2 | METHOD FOR IDENTIFYING INHIBITORS AGAINST CHIKUNGUNYA VIRUS | TIBOTEC PHARMACEUTICALS (IE) | 2012-01-26 | — | — | WO | disclosed |
| EP-1712231-A2 | Method for improving the pharmacokinetics of tipranavir | Pharmacia & Upjohn Company LLC (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1643948-A1 | DIFFUSION LAYER MODULATED SOLIDS | Pharmacia & Upjohn Company LLC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20050042291-A1 | Diffusion layer modulated solids | HAWLEY MICHAEL (US) | 2005-02-24 | — | — | US | disclosed |
| WO-2005004763-A1 | DIFFUSION LAYER MODULATED SOLIDS | PHARMACIA & UPJOHN COMPANY LLC. (US) | 2005-01-20 | — | — | WO | disclosed |
| CN-1154491-C | Method for improving the pharmacokinetics of tipranavir | 法玛西雅厄普约翰美国公司 | 2004-06-23 | — | — | CN | disclosed |
| CN-1324237-A | Method for improving the pharmacokinetics of tipranavir | UPJOHN CO (US) | 2001-11-28 | — | — | CN | disclosed |
| EP-1126847-A1 | METHOD FOR IMPROVING THE PHARMACOKINETICS OF TIPRANAVIR | PHARMACIA & UPJOHN COMPANY (US) | 2001-08-29 | — | — | EP | disclosed |
| US-6147095-A | ADMINISTERING COMBINATION OF TIPRANAVIR AND RITONAVIR FOR TREATMENT OF HIV | PHARMACIA & UPJOHN COMPANY (US) | 2000-11-14 | — | — | US | disclosed |
| WO-2000025784-A1 | METHOD FOR IMPROVING THE PHARMACOKINETICS OF TIPRANAVIR | PHARMACIA & UPJOHN COMPANY (US) | 2000-05-11 | — | — | WO | disclosed |