Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.71 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.70 |
| ▸ | KDR | P35968 | 11/20 | 0.70 |
| ▸ | CSF1R | P07333 | 4/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.70 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.68 |
| ▸ | PLK4 | O00444 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200608 | 1.00 | PRKAA1 (0.71) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL4200611 | 1.00 | PRKAA1 (0.71) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL14276316 | 0.94 | PRKAA1 (0.71) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL14276313 | 0.94 | PRKAA1 (0.71) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL14276359 | 0.93 | PRKAA1 (0.72) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL14276342 | 0.92 | PRKAA1 (0.69) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL14276323 | 0.92 | PRKAA1 (0.69) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL4200636 | 0.92 | PDGFRB (0.69) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL14276321 | 0.92 | KDR (0.70) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL14276334 | 0.92 | KDR (0.70) | PRKAA1PRKAA2PDGFRBKDRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686987-A4 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1686987-A2 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005053614-A2 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-06-16 | — | — | WO | disclosed |