Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2950968 | 0.86 | HTT (0.51) | HTTALDH1A1TSHRUSP2PTGS1 | |
| SCHEMBL2953372 | 0.77 | HTT (0.62) | HTTALDH1A1TSHRKCNH2USP2 | |
| SCHEMBL2951260 | 0.77 | HTT (0.44) | HTTALDH1A1TSHRPTGS1 | |
| SCHEMBL2954936 | 0.75 | HTT (0.37) | HTTKMO | |
| SCHEMBL13108719 | 0.75 | HTT (0.68) | HTTALDH1A1TSHRUSP2 | |
| SCHEMBL3108623 | 0.74 | CYP3A4 (0.39) | HTTALDH1A1TSHRUSP2KMO | |
| SCHEMBL3033382 | 0.73 | HTT (0.51) | HTTALDH1A1TSHR | |
| SCHEMBL9103530 | 0.68 | MCL1 (0.38) | CHRM5FFAR4 | |
| SCHEMBL15797310 | 0.68 | HTT (0.51) | HTTALDH1A1TSHRUSP2 | |
| SCHEMBL922179 | 0.68 | KCNH2 (0.63) | KCNH2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275571-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275571-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | UTS2R, AVPR2, VIPR2 | HTT 527/4885ALDH1A1 4201/4885TSHR 2055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.