Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4349663 | 0.91 | KDM4E (0.59) | KDM4EL3MBTL1KMT2ARARARARB | |
| SCHEMBL12035329 | 0.88 | KDM4E (0.56) | KDM4ESMN1; SMN2KMT2ARARARARB | |
| SCHEMBL11939094 | 0.88 | KDM4E (0.56) | KDM4ESMN1; SMN2L3MBTL1RARARARB | |
| SCHEMBL12035436 | 0.87 | KDM4E (0.55) | KDM4ESMN1; SMN2L3MBTL1KMT2ARARA | |
| SCHEMBL4362439 | 0.86 | KDM4E (0.54) | KDM4ERARARARBRARGMAPK1 | |
| SCHEMBL4352101 | 0.86 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL4349388 | 0.85 | MAPT (0.54) | KDM4ESMN1; SMN2L3MBTL1KMT2AGAA | |
| SCHEMBL12340092 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL4348385 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL12035446 | 0.83 | KDM4E (0.51) | KDM4EL3MBTL1KMT2ARARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110312992-A1 | Inhibitors of C-Kit and Uses Thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2011-12-22 | — | — | US | claimed |
| US-20120302565-A1 | KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF | M.D. ANDERSON CANCER CENTER (US) | 2012-11-29 | — | — | US | disclosed |
| US-8268809-B2 | Kinase inhibitors for preventing or treating pathogen infection and method of use thereof | EMORY UNIVERSITY (US) | 2012-09-18 | — | — | US | disclosed |
| EP-2471529-A2 | Kinase Inhibitors for Preventing or Treating Pathogen Infection and Method of Use Thereof | Emory University (US) | 2012-07-04 | — | — | EP | disclosed |
| US-20110312992-A1 | Inhibitors of C-Kit and Uses Thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2011-12-22 | — | — | US | disclosed |
| US-20110312992-A1 | Inhibitors of C-Kit and Uses Thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2011-12-22 | — | — | US | disclosed |
| EP-2364702-A2 | Kinase inhibitors for preventing or treating pathogen infection and method of use thereof | Emory University (US) | 2011-09-14 | — | — | EP | disclosed |
| US-20090281115-A1 | INHIBITORS OF C-KIT AND USES THEREOF | Board of Regents, The University of Texas System, a Texas University (US) | 2009-11-12 | — | — | US | disclosed |
| WO-2008079460-A2 | TYROSINE KINASE INHIBITORS FOR PREVENTION OR TREATMENT OF INFECTION | EMORY UNIVERSITY (US) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008005877-A2 | INHIBITORS OF C-KIT AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008005877-A2 | INHIBITORS OF C-KIT AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312992-A1 | Inhibitors of C-Kit and Uses Thereof | KIT, CHUK, MASTL | KDM4E 702/4885TRPA1 4836/4885ALDH1A1 1229/4885 |
| US-20120302565-A1 | KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF | MAP3K1, MAP3K2, MAP3K6 | KDM4E 1924/4885TRPA1 4300/4885ALDH1A1 4507/4885 |
| US-20090281115-A1 | INHIBITORS OF C-KIT AND USES THEREOF | KIT, CHUK, MASTL | KDM4E 702/4885TRPA1 4836/4885ALDH1A1 1229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.