Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.61 |
| ▸ | FBP1 | P09467 | 2/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.55 |
| ▸ | TEK | Q02763 | 1/20 | 0.55 |
| ▸ | CD38 | P28907 | 1/20 | 0.55 |
| ▸ | TDP2 | O95551 | 1/20 | 0.55 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6190100 | 0.91 | CD38 (0.66) | EGFRFBP1ERBB2AURKBAURKA | |
| SCHEMBL4364048 | 0.80 | MEN1 (0.61) | EGFRFBP1ERBB2AURKBAURKA | |
| SCHEMBL28119911 | 0.78 | EGFR (0.70) | EGFRFBP1ERBB2AURKBAURKA | |
| SCHEMBL4364036 | 0.77 | EGFR (0.60) | EGFRFBP1ERBB2AURKBAURKA | |
| SCHEMBL4356776 | 0.77 | EGFR (0.63) | EGFRFBP1ERBB2AURKBAURKA | |
| SCHEMBL28403915 | 0.77 | EGFR (0.74) | EGFRFBP1ERBB2AURKBAURKA | |
| Hydrochloric Acid SCHEMBL7486055 | 0.77 | EGFR (0.69) | EGFRFBP1ERBB2AURKBAURKA | |
| SCHEMBL30301821 | 0.76 | EGFR (1.00) | EGFRFBP1ERBB2AURKBAURKA | |
| SCHEMBL1734685 | 0.76 | EGFR (1.00) | EGFRFBP1ERBB2AURKBAURKA | |
| SCHEMBL4741932 | 0.76 | EGFR (0.67) | EGFRERBB2CD38RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880517-B1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-01-16 | — | — | EP | claimed |
| EP-0880517-A1 | QUINAZOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | claimed |
| WO-1997030044-A1 | QUINAZOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-0880517-B1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-01-16 | — | — | EP | disclosed |
| EP-0880517-A1 | QUINAZOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| US-5814630-A | USEFUL AS RECEPTOR TYROSINE KINASE INHIBITORS IN THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-09-29 | — | — | US | disclosed |
| WO-1997030044-A1 | QUINAZOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |