Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | STK4 | Q13043 | 1/20 | 0.45 |
| ▸ | STK3 | Q13188 | 1/20 | 0.45 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.45 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 11/20 | 0.44 |
| ▸ | JAK1 | P23458 | 11/20 | 0.44 |
| ▸ | JAK3 | P52333 | 11/20 | 0.44 |
| ▸ | TYK2 | P29597 | 10/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4361523 | 0.95 | ALK (0.45) | ALKRAB9ANPC1STK4STK3 | |
| SCHEMBL4359278 | 0.91 | ALK (0.52) | ALKSTK4STK3STK26STK24 | |
| Trifluoroacetic Acid SCHEMBL4360863 | 0.88 | ALK (0.48) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL4365357 | 0.88 | ALK (0.48) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL13632965 | 0.86 | ALK (0.50) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL4368492 | 0.86 | ALK (0.55) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL4365390 | 0.84 | ALK (0.49) | ALKSTK4STK3STK26STK24 | |
| Trifluoroacetic Acid SCHEMBL4356429 | 0.83 | ALK (0.44) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL4361639 | 0.83 | ALK (0.49) | ALKRAB9ANPC1STK4STK3 | |
| SCHEMBL4360597 | 0.82 | ALK (0.51) | ALKSTK4STK3STK26STK24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | claimed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | claimed |
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | ALK 3/4885RAB9A 1998/4885NPC1 2849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.