Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.46 |
| ▸ | CTSD | P07339 | 15/20 | 0.46 |
| ▸ | CTSE | P14091 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359790 | 0.86 | BACE1 (0.49) | BACE1CTSDCTSE | |
| SCHEMBL2528514 | 0.84 | BACE1 (0.66) | BACE1CTSDCTSE | |
| SCHEMBL3937290 | 0.78 | BACE1 (0.54) | BACE1CTSDCTSE | |
| SCHEMBL4351534 | 0.77 | BACE1 (0.70) | BACE1CTSDCTSE | |
| SCHEMBL4353947 | 0.76 | BACE1 (0.41) | BACE1CTSDCTSE | |
| SCHEMBL4174750 | 0.72 | BACE1 (0.48) | BACE1CTSDCTSE | |
| SCHEMBL2530306 | 0.70 | BACE1 (0.70) | BACE1CTSDCTSE | |
| SCHEMBL4355805 | 0.70 | BACE1 (0.53) | BACE1CTSDCTSE | |
| SCHEMBL4181171 | 0.68 | BACE1 (0.56) | BACE1CTSDCTSE | |
| SCHEMBL4181168 | 0.68 | BACE1 (0.56) | BACE1CTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312370-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312370-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | BACE2, BACE1, APP | BACE1 2/4885CTSD 16/4885CTSE 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.