Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.78 |
| ▸ | GMPS | P49915 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19001586 | 0.91 | EGFR (0.70) | EGFRERBB2GMPS | |
| SCHEMBL13755819 | 0.88 | EGFR (1.00) | EGFRERBB2GMPSMAPK1 | |
| SCHEMBL4586985 | 0.88 | EGFR (0.78) | EGFRERBB2GMPS | |
| SCHEMBL8870629 | 0.87 | EGFR (0.69) | EGFRERBB2GMPSMAPK1 | |
| SCHEMBL4585935 | 0.87 | EGFR (1.00) | EGFRERBB2GMPS | |
| SCHEMBL4585990 | 0.87 | EGFR (1.00) | EGFRERBB2GMPS | |
| SCHEMBL2100347 | 0.86 | EGFR (0.77) | EGFRERBB2MAPK1 | |
| SCHEMBL22971857 | 0.86 | GMPS (1.00) | EGFRERBB2GMPS | |
| SCHEMBL31318107 | 0.86 | GMPS (1.00) | EGFRERBB2GMPS | |
| SCHEMBL8871406 | 0.85 | EGFR (0.66) | EGFRERBB2GMPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5457105-A | anticancer use; e.g. 4-(3'-chloro-4'-fluoroanilino)-6,7-dimethoxyquinazoline (gefitinib) | ZENECA LIMITED (GB) | 1995-10-10 | — | — | US | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| US-5616582-A | Use as anticancer agents; e.g. gefitinib | ZENECA LIMITED (GB) | 1997-04-01 | — | — | US | disclosed |
| EP-0566226-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1995-11-08 | — | — | EP | disclosed |
| US-5457105-A | anticancer use; e.g. 4-(3'-chloro-4'-fluoroanilino)-6,7-dimethoxyquinazoline (gefitinib) | ZENECA LIMITED (GB) | 1995-10-10 | — | — | US | disclosed |
| EP-0566226-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1993-10-20 | — | — | EP | disclosed |