Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.69 |
| ▸ | HTT | P42858 | 4/20 | 0.69 |
| ▸ | FADS1 | O60427 | 1/20 | 0.69 |
| ▸ | AHR | P35869 | 1/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.69 |
| ▸ | LTK | P29376 | 2/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.69 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.69 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.69 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.69 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586872 | 0.84 | EGFR (0.80) | EGFRAHRERBB2 | |
| SCHEMBL4393321 | 0.83 | AHR (0.97) | EGFRABCG2HTTFADS1AHR | |
| SCHEMBL5570698 | 0.83 | EGFR (0.75) | EGFRABCG2HTTFADS1AHR | |
| SCHEMBL29941271 | 0.82 | EGFR (1.00) | EGFRABCG2HTTFADS1AHR | |
| SCHEMBL8920 | 0.82 | EGFR (1.00) | EGFRABCG2HTTFADS1AHR | |
| SCHEMBL5144493 | 0.82 | EGFR (0.69) | EGFRABCG2HTTFADS1AHR | |
| SCHEMBL2992623 | 0.82 | EGFR (1.00) | EGFRABCG2HTTFADS1AHR | |
| SCHEMBL5569900 | 0.82 | HTT (1.00) | EGFRABCG2HTTFADS1AHR | |
| SCHEMBL29352479 | 0.82 | EGFR (1.00) | EGFRABCG2HTTFADS1AHR | |
| SCHEMBL668559 | 0.82 | EGFR (1.00) | EGFRABCG2HTTFADS1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | claimed |
| EP-0520722-A1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | disclosed |
| EP-0520722-A1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |