Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.77 |
| ▸ | PDE6D | O43924 | 1/20 | 0.66 |
| ▸ | PDE6A | P16499 | 1/20 | 0.66 |
| ▸ | PDE6G | P18545 | 1/20 | 0.66 |
| ▸ | PDE6B | P35913 | 1/20 | 0.66 |
| ▸ | PDE6C | P51160 | 1/20 | 0.66 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4357634 | 0.91 | PDE5A (0.73) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7163577 | 0.87 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4352879 | 0.86 | MAPT (0.65) | PDE5AMAPTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL8883700 | 0.85 | PDE5A (0.64) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL10681731 | 0.84 | PDE5A (0.62) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL10670455 | 0.82 | PDE5A (0.60) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL8884082 | 0.81 | MAPT (0.72) | PDE5AMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8883779 | 0.81 | MAPT (0.64) | PDE5AMAPTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL4363819 | 0.81 | AURKB (0.62) | PDE5AMAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL651326 | 0.80 | PDE5A (0.56) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| US-5650415-A | INHIBITORS OF CELL PROLIFERATION/DIFFERENTIATION, ANTITUMOR, ANTICANCER, TREATMENT OF FIBROTIC DISORDERS, BLOOD VESSEL PROLIFERATION | SUGEN, INC. (US) | 1997-07-22 | — | — | US | disclosed |