Sugi Predict

Sugi Predict / Compounds / SCHEMBL4358458

SCHEMBL4358458

SCHEMBL4358458

Cc1cnc2nc1Nc1cccc(c1)/C=C\c1cccc(c1)N2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK2 O60674 14/20 0.40
▸ PTK2 Q05397 1/20 0.39
▸ PTK2B Q14289 1/20 0.39
▸ STK26 Q9P289 1/20 0.39
▸ STK24 Q9Y6E0 1/20 0.39
▸ CDK2 P24941 2/20 0.38
▸ GAK O14976 2/20 0.38
▸ EPHA2 P29317 2/20 0.38
▸ CDK1 P06493 1/20 0.38
▸ KDR P35968 1/20 0.38
▸ ALK Q9UM73 6/20 0.37
▸ JAK1 P23458 12/20 0.37
▸ JAK3 P52333 12/20 0.37
▸ TYK2 P29597 10/20 0.36
▸ PDPK1 O15530 1/20 0.34
▸ CCNA2 P20248 1/20 0.34
▸ FLT3 P36888 1/20 0.34
▸ CCNA1 P78396 1/20 0.34
▸ ABL1 P00519 1/20 0.33
▸ FGFR1 P11362 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL1075059 0.89 PTK2 (0.40) JAK2PTK2PTK2BSTK26STK24
SCHEMBL4354832 0.81 ALK (0.55) JAK2STK26STK24ALKJAK1
SCHEMBL12700703 0.80 ALK (0.46) JAK2STK26STK24ALKJAK1
SCHEMBL12700712 0.79 PTK2 (0.52) JAK2PTK2PTK2BCDK2GAK
SCHEMBL1076585 0.74 ALK (0.46) JAK2STK26STK24GAKEPHA2
Trifluoroacetic Acid SCHEMBL1073799 0.73 ALK (0.43) JAK2PTK2PTK2BSTK26STK24
Trifluoroacetic Acid SCHEMBL1076667 0.72 ALK (0.47) JAK2PTK2PTK2BSTK26STK24
SCHEMBL4357238 0.72 ALK (0.54) JAK2STK26STK24ALKJAK1
Trifluoroacetic Acid SCHEMBL1075614 0.69 ALK (0.40) JAK2PTK2PTK2BSTK26STK24
SCHEMBL12700738 0.68 ALK (0.67) JAK2PTK2PTK2BSTK26STK24

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8871753-B2 Macrocyclic compounds and their use as kinase inhibitors INCYTE CORPORATION (US) 2014-10-28 — — US claimed
US-20090286778-A1 MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS INCYTE CORPORATION (US) 2009-11-19 — — US claimed
US-8871753-B2 Macrocyclic compounds and their use as kinase inhibitors INCYTE CORPORATION (US) 2014-10-28 — — US disclosed
US-8871753-B2 Macrocyclic compounds and their use as kinase inhibitors INCYTE CORPORATION (US) 2014-10-28 — — US disclosed
US-20090286778-A1 MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS INCYTE CORPORATION (US) 2009-11-19 — — US disclosed
US-20090286778-A1 MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS INCYTE CORPORATION (US) 2009-11-19 — — US disclosed
WO-2009132202-A2 MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS INCYTE CORPORATION (US) 2009-10-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286778-A1 MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS JAK2, JAK1, ALK JAK2 1/4885PTK2 527/4885PTK2B 326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.