Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.74 |
| ▸ | HRH1 | P35367 | 1/20 | 0.74 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586374 | 0.87 | HRH3 (0.72) | HRH3HRH1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4673719 | 0.86 | HRH3 (0.56) | HRH3HRH1KMT2ACA12CA1 | |
| SCHEMBL14006742 | 0.86 | HRH3 (0.77) | HRH3HRH1 | |
| SCHEMBL5275285 | 0.85 | HRH3 (1.00) | HRH3HRH1PRKAA2CA12CA1 | |
| SCHEMBL4670675 | 0.81 | HRH3 (0.50) | HRH3HRH1KMT2A | |
| SCHEMBL6472123 | 0.79 | HRH3 (0.63) | HRH3HRH1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1807688 | 0.79 | HRH3 (0.63) | HRH3HRH1PRKAA2KMT2ACA12 | |
| SCHEMBL3577920 | 0.78 | HRH3 (0.56) | HRH3KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL5203383 | 0.78 | HRH3 (0.67) | HRH3MAPT | |
| SCHEMBL121598 | 0.77 | HRH3 (0.67) | HRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615550-B2 | Substituted piperazines,(1,4) diazepines, and 2,5-diazabicyclo (2.2.1)iieptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists | GLAXO GROUP LIMITED (GB) | 2009-11-10 | — | — | US | claimed |