Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 6/20 | 0.35 |
| ▸ | JAK1 | P23458 | 6/20 | 0.35 |
| ▸ | TYK2 | P29597 | 6/20 | 0.35 |
| ▸ | JAK3 | P52333 | 6/20 | 0.35 |
| ▸ | STK4 | Q13043 | 1/20 | 0.34 |
| ▸ | STK3 | Q13188 | 1/20 | 0.34 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.34 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4361561 | 0.97 | ALK (0.46) | ALKALDH1A1JAK2JAK1TYK2 | |
| Trifluoroacetic Acid SCHEMBL4361071 | 0.96 | ALK (0.47) | ALKALDH1A1USP2TDP1CYP3A4 | |
| SCHEMBL1076245 | 0.95 | ALK (0.50) | ALKALDH1A1USP2TDP1CYP3A4 | |
| SCHEMBL4363395 | 0.92 | ALK (0.49) | ALKALDH1A1USP2JAK2JAK1 | |
| SCHEMBL4357322 | 0.91 | ALK (0.51) | ALKALDH1A1USP2TDP1CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL4358083 | 0.91 | ALK (0.47) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL1076455 | 0.90 | ALK (0.48) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL4359097 | 0.90 | ALK (0.51) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL4361064 | 0.89 | ALK (0.46) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL4361043 | 0.89 | ALK (0.48) | ALKALDH1A1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | ALK 3/4885ALDH1A1 2511/4885USP2 2291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.