Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 12/20 | 0.85 |
| ▸ | KDR | P35968 | 11/20 | 0.85 |
| ▸ | EPHB4 | P54760 | 10/20 | 0.77 |
| ▸ | EGFR | P00533 | 7/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.69 |
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | INSR | P06213 | 1/20 | 0.69 |
| ▸ | FBP1 | P09467 | 1/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.69 |
| ▸ | FLT4 | P35916 | 1/20 | 0.69 |
| ▸ | CLK1 | P49759 | 1/20 | 0.69 |
| ▸ | TEK | Q02763 | 1/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.69 |
| ▸ | RET | P07949 | 1/20 | 0.69 |
| ▸ | KIF5B | P33176 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL906797 | 0.92 | EPHA2 (1.00) | EPHA2KDREPHB4EGFRERBB2 | |
| SCHEMBL9259 | 0.90 | KDR (0.77) | EPHA2KDREPHB4EGFRERBB2 | |
| SCHEMBL7221058 | 0.90 | EPHA2 (0.70) | EPHA2KDREPHB4EGFRFBP1 | |
| SCHEMBL7219862 | 0.90 | EPHA2 (0.70) | EPHA2KDREPHB4EGFRFBP1 | |
| SCHEMBL7221051 | 0.90 | EPHA2 (0.70) | EPHA2KDREPHB4EGFRFBP1 | |
| SCHEMBL6989639 | 0.90 | EPHA2 (0.70) | EPHA2KDREPHB4EGFRFBP1 | |
| SCHEMBL907202 | 0.90 | EPHA2 (0.95) | EPHA2KDREPHB4EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL7219208 | 0.90 | KDR (0.69) | EPHA2KDREPHB4EGFRERBB2 | |
| SCHEMBL6991150 | 0.89 | EPHA2 (0.69) | EPHA2KDREPHB4EGFRERBB2 | |
| SCHEMBL7218842 | 0.89 | EPHA2 (0.69) | EPHA2KDREPHB4EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892799-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-22 | — | — | EP | claimed |
| US-5770603-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1998-06-23 | — | — | US | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-0892799-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-22 | — | — | EP | disclosed |
| EP-0892799-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1999-01-27 | — | — | EP | disclosed |
| US-5770603-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |
| WO-1997038994-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-10-23 | — | — | WO | disclosed |