Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.51 |
| ▸ | PDE5A | O76074 | 6/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.50 |
| ▸ | MIF | P14174 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3186177 | 0.84 | PDE4B (0.51) | PDE4BPDE5APDE3AMIFADORA2A | |
| SCHEMBL12897932 | 0.77 | PDE4B (0.50) | PDE4BPDE5APDE3AMIFADORA2A | |
| SCHEMBL3202954 | 0.77 | PDE4B (0.56) | PDE4BPDE5APDE3AMIFADORA2A | |
| SCHEMBL3194316 | 0.77 | PDE4B (0.52) | PDE4BPDE5APDE3AMIFADORA2A | |
| SCHEMBL1268920 | 0.76 | PDE4B (0.49) | PDE4BPDE5APDE3AMIFADORA2A | |
| SCHEMBL3201178 | 0.76 | PDE4B (0.54) | PDE4BPDE5APDE3AMIFADORA2A | |
| SCHEMBL1270088 | 0.74 | PDE4B (0.47) | PDE4BPDE5APDE3AMIFADORA2A | |
| SCHEMBL3197217 | 0.74 | PDE4B (0.52) | PDE4BPDE5APDE3AMIFADORA2A | |
| SCHEMBL1269980 | 0.74 | PDE4B (0.52) | PDE4BPDE5APDE3AMIFADORA2A | |
| SCHEMBL3195918 | 0.74 | PDE4B (0.52) | PDE4BPDE5APDE3AMIFADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038279-A2 | SUBSTITUTED PYRAZOLO [1,5- ALPHA] PYRIDINE COMPOUNDS AND THEIR METHODS OF USE | Avigen, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007146087-A2 | SUBSTITUTED PYRAZOLO [1,5-α] PYRIDINE COMPOUNDS AND THEIR METHODS OF USE | AVIGEN, INC. (US) | 2007-12-21 | — | — | WO | disclosed |