SCHEMBL4359667

SCHEMBL4359667

Cc1cccc(C(N)=O)c1C1CCCC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR5 P32302 1/20 0.52
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
KDM4E B2RXH2 2/20 0.42
MEN1 O00255 1/20 0.42
MAPT P10636 1/20 0.42
KMT2A Q03164 1/20 0.42
TAS1R3 Q7RTX0 2/20 0.41
TAS1R1 Q7RTX1 2/20 0.41
TAS1R2 Q8TE23 2/20 0.41
ALDH1A1 P00352 2/20 0.41
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.41
HTR1A P08908 3/20 0.40
PARP1 P09874 3/20 0.40
POLB P06746 1/20 0.40
HTT P42858 1/20 0.40
ESR2 Q92731 1/20 0.40
TP53 P04637 1/20 0.39
SLC6A2 P23975 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31074260 0.98 CXCR5 (0.51) CXCR5NPC1RAB9AKDM4EMEN1
SCHEMBL4141784 0.98 CXCR5 (0.51) CXCR5NPC1RAB9AKDM4EMEN1
SCHEMBL3840452 0.93 CXCR5 (0.45) CXCR5KDM4EALDH1A1HPGDHSD17B10
SCHEMBL1990045 0.88 PARP1 (0.44) NPC1KDM4EMEN1MAPTKMT2A
SCHEMBL20822489 0.86 CYP11B1 (0.42) CXCR5KDM4EALDH1A1HPGDHSD17B10
SCHEMBL3809365 0.86 PARP1 (0.51) PARP1
SCHEMBL18304680 0.83 CXCR5 (0.55) CXCR5NPC1RAB9AKDM4EMEN1
SCHEMBL18304683 0.83 CXCR5 (0.55) CXCR5NPC1RAB9AKDM4EMEN1
SCHEMBL28020430 0.81 PARP1 (0.40) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL14688546 0.81 CXCR5 (0.60) CXCR5NPC1RAB9AKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1611109-A4 NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF TAISHO PHARMACEUTICAL CO LTD (JP) 2009-06-24 EP claimed
JP-2006522109-A 2006-09-28 JP claimed
EP-1611109-A1 NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF TAISHO PHARMACEUTICAL CO., LTD (JP) 2006-01-04 EP claimed
WO-2004087680-A1 NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF TAISHO PHARMACEUTICAL CO., LTD. (JP) 2004-10-14 WO claimed
US-7126027-B2 N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives AKZO NOBEL N.V. (NL) 2006-10-24 US disclosed