Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366298 | 0.95 | ALK (0.54) | ALKLCKMETAP2ADORA1PDE4B | |
| SCHEMBL13633121 | 0.88 | ALK (0.43) | ALKLCKMETAP2ADORA1PDE4B | |
| Trifluoroacetic Acid SCHEMBL4359557 | 0.87 | ALK (0.60) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL4359450 | 0.87 | ALK (0.59) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL4359417 | 0.86 | ALK (0.50) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL1075661 | 0.86 | ALK (0.51) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL4361442 | 0.86 | ALK (0.50) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL4354278 | 0.85 | ALK (0.49) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL4365033 | 0.85 | ALK (0.48) | ALKJAK2JAK1TYK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL4364760 | 0.84 | ALK (0.52) | ALKLCKJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | ALK 3/4885LCK 13/4885CACNA1B 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.