SCHEMBL4360133

SCHEMBL4360133

CCCCOC(=O)[C@@]1(N)[C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(=O)OC

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 4/20 0.62
GRM3 Q14832 4/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL230227 0.93 GRM2 (0.62) GRM2GRM3
SCHEMBL1226470 0.92 GRM2 (0.75) GRM2GRM3
SCHEMBL232546 0.92 GRM2 (0.75) GRM2GRM3
SCHEMBL231356 0.90 GRM2 (0.75) GRM2GRM3
SCHEMBL2001339 0.89 GRM2 (0.72) GRM2GRM3
SCHEMBL232279 0.88 GRM2 (0.73) GRM2GRM3
SCHEMBL2010532 0.87 GRM2 (0.72) GRM2GRM3
SCHEMBL2001336 0.87 GRM2 (0.72) GRM2GRM3
SCHEMBL2007376 0.87 GRM2 (0.72) GRM2GRM3
SCHEMBL2003529 0.87 GRM2 (0.72) GRM2GRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2123630-A1 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative Taisho Pharmaceutical Co. Ltd. (JP) 2009-11-25 EP disclosed