Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 11/20 | 0.47 |
| ▸ | CNR1 | P21554 | 7/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359913 | 1.00 | AVPR1A (0.47) | AVPR1ACNR1CNR2DRD5SLC6A2 | |
| SCHEMBL13602998 | 0.93 | AVPR1A (0.47) | AVPR1ACNR1CNR2DRD5SLC6A2 | |
| SCHEMBL4361016 | 0.91 | AVPR1A (0.54) | AVPR1ACNR1NPY5R | |
| SCHEMBL4361012 | 0.91 | AVPR1A (0.54) | AVPR1ACNR1NPY5R | |
| SCHEMBL4363622 | 0.91 | AVPR1A (0.46) | AVPR1ACNR1 | |
| SCHEMBL5137938 | 0.91 | AVPR1A (0.46) | AVPR1ACNR1 | |
| SCHEMBL4356779 | 0.90 | AVPR1A (0.45) | AVPR1ACNR1CNR2PSEN1PSEN2 | |
| SCHEMBL4358446 | 0.90 | AVPR1A (0.45) | AVPR1ACNR1CNR2PSEN1PSEN2 | |
| SCHEMBL4365719 | 0.88 | AVPR1A (0.50) | AVPR1ACNR1CNR2DRD5SLC6A2 | |
| Hydrochloric Acid SCHEMBL5137245 | 0.87 | AVPR1A (0.49) | AVPR1ACNR1CNR2DRD5SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904477-B1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2009-01-21 | — | — | EP | claimed |
| EP-2052292-A2 | METHOD OF PREPARING A PATTERNED FILM WITH A DEVELOPING SOLVENT | Dow Corning Corporation (US) | 2009-04-29 | — | — | EP | disclosed |
| EP-1904477-A1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2008021125-A2 | METHOD OF PREPARING A PATTERNED FILM WITH A DEVELOPING SOLVENT | DOW CORNING CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2007006688-A1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |