Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 10/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2515048 | 1.00 | IDO1 (0.61) | IDO1SMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL2515050 | 1.00 | IDO1 (0.61) | IDO1SMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL2518175 | 0.90 | IDO1 (0.49) | IDO1MEN1KMT2A | |
| SCHEMBL2518177 | 0.90 | IDO1 (0.49) | IDO1MEN1KMT2A | |
| SCHEMBL12230824 | 0.90 | IDO1 (0.49) | IDO1MEN1KMT2A | |
| SCHEMBL2516645 | 0.90 | IDO1 (0.61) | IDO1 | |
| SCHEMBL2516648 | 0.90 | IDO1 (0.61) | IDO1 | |
| SCHEMBL12054238 | 0.88 | IDO1 (0.55) | IDO1SMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL30209401 | 0.88 | IDO1 (0.77) | IDO1RAB9AHTTTP53ALDH1A1 | |
| SCHEMBL16366474 | 0.88 | IDO1 (0.48) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879573-A4 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORP (US) | 2009-07-08 | — | — | EP | claimed |
| EP-1879573-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | Incyte Corporation (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006122150-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2006-11-16 | — | — | WO | claimed |