Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 10/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.39 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1412183 | 1.00 | EPHX1 (0.62) | EPHX1EPHX2POLBNPC1RAB9A | |
| SCHEMBL8959925 | 1.00 | EPHX1 (0.62) | EPHX1EPHX2POLBNPC1RAB9A | |
| SCHEMBL1412186 | 1.00 | EPHX1 (0.62) | EPHX1EPHX2POLBNPC1RAB9A | |
| SCHEMBL241447 | 0.87 | EPHX1 (0.74) | EPHX1EPHX2POLBNPC1RAB9A | |
| SCHEMBL241446 | 0.87 | EPHX1 (0.74) | EPHX1EPHX2POLBNPC1RAB9A | |
| SCHEMBL3910751 | 0.87 | EPHX1 (0.74) | EPHX1EPHX2POLBNPC1RAB9A | |
| SCHEMBL13459981 | 0.83 | EPHX1 (0.78) | EPHX1EPHX2POLBNPC1RAB9A | |
| SCHEMBL9003889 | 0.82 | EPHX2 (0.61) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1412068 | 0.82 | EPHX2 (0.61) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28171895 | 0.80 | EPHX1 (0.95) | EPHX1EPHX2POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018388-A2 | BISADENOSINE COMPOUNDS AS ADENOSINE A2A RECEPTOR AGONISTS | Novartis AG (CH) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007121924-A2 | BISADENOSINE COMPOUNDS AS ADENOSINE A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2007-11-01 | — | — | WO | disclosed |