Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.78 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | TP53 | P04637 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | PGR | P06401 | 2/20 | 0.78 |
| ▸ | ESRRG | P62508 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.78 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.78 |
| ▸ | PLD2 | O14939 | 1/20 | 0.78 |
| ▸ | ESRRB | O95718 | 1/20 | 0.78 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4364511 | 1.00 | ESR1 (0.78) | ESR1ESR2MAPTCYP3A4MEN1 | |
| SCHEMBL22133713 | 0.92 | ESR1 (0.77) | ESR1ESR2MAPTCYP3A4MEN1 | |
| SCHEMBL24514577 | 0.91 | ESR1 (0.75) | ESR1ESR2MAPTCYP3A4MEN1 | |
| SCHEMBL12468678 | 0.89 | ESR1 (0.72) | ESR1ESR2MAPTCYP3A4MEN1 | |
| SCHEMBL12468676 | 0.89 | ESR1 (0.72) | ESR1ESR2MAPTCYP3A4MEN1 | |
| SCHEMBL21499295 | 0.89 | ESR1 (0.72) | ESR1ESR2MAPTCYP3A4MEN1 | |
| SCHEMBL12282850 | 0.89 | ESR1 (0.72) | ESR1ESR2MAPTCYP3A4MEN1 | |
| Afimoxifene SCHEMBL7649812 | 0.88 | ESR1 (0.91) | ESR1ESR2MAPTCYP3A4MEN1 | |
| Afimoxifene SCHEMBL7649806 | 0.88 | ESR1 (0.91) | ESR1ESR2MAPTCYP3A4MEN1 | |
| SCHEMBL15668666 | 0.88 | ESR1 (1.00) | ESR1ESR2MAPTCYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120999-A2 | USE OF AN ENDOXIFEN PRODRUG FOR TREATMENT OF BREAST CANCER | OLEMA PHARMACEUTICALS, INC. (US) | 2009-10-01 | — | — | WO | disclosed |