Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.68 |
| ▸ | PDE4A | P27815 | 9/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369697 | 0.91 | PDE4B (0.83) | PDE4BPDE4DPDE4APDE4CEPHA2 | |
| SCHEMBL13624574 | 0.84 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CEPHA2 | |
| SCHEMBL4365705 | 0.84 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6586279 | 0.81 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4361797 | 0.81 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14311705 | 0.80 | PDE4B (0.72) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4361769 | 0.80 | PDE4B (0.72) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4366173 | 0.80 | PDE4B (0.67) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4361746 | 0.79 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4371694 | 0.79 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4CEPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291950-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | KALYPSYS, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090291950-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | KALYPSYS, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090291950-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | KALYPSYS, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| WO-2008006052-A2 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | GOVEK STEVEN P (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291950-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | PDE4A, PDE4B, PDE4C | PDE4B 2/4885PDE4D 4/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.