Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437323 | 0.79 | NPC1 (0.47) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL7745875 | 0.68 | MAPT (0.76) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL30739780 | 0.67 | NPC1 (0.68) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL2564890 | 0.67 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL398064 | 0.66 | NPC1 (0.46) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL6250922 | 0.66 | MAPT (0.72) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL6054953 | 0.66 | NPC1 (0.69) | NPC1RAB9AMEN1MAPTKMT2A | |
| Iodide SCHEMBL30758553 | 0.66 | NPC1 (0.96) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL9197688 | 0.66 | PTPN1 (0.65) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL10605853 | 0.65 | KCNK3 (0.69) | NPC1RAB9AMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101612-B2 | N-3-isoxazolyl-4-methyl-3-(1-((1-methylethyl)oxy)-6-phthalazinyl)benzamide; p38 kinase inhibitor; antiinflammatory, analgesic agent; rheumatoid arthritis, osteoporosis, leukemia, psoriasis, Crohn's disease, rhinitis, ulcerative colitis, dermatitis, asthma, Alzheimer's disease, type I and II diabetes | AMGEN INC. (US) | 2012-01-24 | — | — | US | disclosed |