Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459650 | 0.81 | S1PR1 (0.59) | S1PR1MAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL436579 | 0.81 | S1PR1 (0.73) | S1PR1S1PR3 | |
| SCHEMBL16649407 | 0.79 | S1PR1 (0.60) | S1PR1HDAC1HDAC8HDAC6FFAR1 | |
| SCHEMBL435271 | 0.74 | S1PR1 (0.65) | S1PR1S1PR3 | |
| SCHEMBL16649359 | 0.71 | S1PR1 (0.54) | S1PR1HDAC1HDAC8HDAC6FFAR1 | |
| SCHEMBL877139 | 0.67 | S1PR1 (1.00) | S1PR1S1PR3 | |
| SCHEMBL436892 | 0.65 | EPHX2 (0.52) | FFAR1 | |
| SCHEMBL876952 | 0.65 | S1PR1 (0.82) | S1PR1S1PR3 | |
| SCHEMBL461254 | 0.65 | S1PR1 (0.86) | S1PR1S1PR3 | |
| SCHEMBL459685 | 0.65 | S1PR1 (0.72) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595969-A1 | SUBSTITUTED 3-PHENYL-1,2,4-OXADIAZOLE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012477-A1 | SUBSTITUTED 3-PHENYL-1,2,4-OXADIAZOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-01-26 | — | — | WO | disclosed |