Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ATR | Q13535 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3760358 | 0.83 | TP53 (0.48) | TP53MDM2KMT2AHPGDMAPK1 | |
| SCHEMBL4366296 | 0.80 | TP53 (0.43) | TP53MDM2GRM5KMT2AHPGD | |
| SCHEMBL3760361 | 0.78 | TP53 (0.48) | TP53MDM2KMT2AHPGDMAPK1 | |
| SCHEMBL3761663 | 0.67 | KMT2A (0.49) | TP53MDM2KMT2AHPGDMAPK1 | |
| SCHEMBL4003843 | 0.67 | KMT2A (0.46) | KMT2AHPGDMAPK1HTTALDH1A1 | |
| SCHEMBL3765786 | 0.66 | HPGD (0.46) | TP53MDM2KMT2AHPGDMAPK1 | |
| SCHEMBL3759329 | 0.65 | HPGD (0.44) | TP53MDM2KMT2AHPGDMAPK1 | |
| SCHEMBL3759007 | 0.64 | HTT (0.48) | TP53MDM2KMT2AHPGDMAPK1 | |
| SCHEMBL3764989 | 0.64 | SMN1; SMN2 (0.44) | TP53MDM2KMT2AHPGDMAPK1 | |
| SCHEMBL3765611 | 0.64 | KMT2A (0.51) | KMT2AHPGDMAPK1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029570-A1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007141504-A1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2007-12-13 | — | — | WO | disclosed |