SCHEMBL4366807

SCHEMBL4366807

CC(Nc1c(Nc2ccncc2)c(=O)c1=O)c1cccc(-c2ccccc2)c1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 19/20 0.79
ROCK1 Q13464 2/20 0.79
AURKB Q96GD4 2/20 0.79
DCLK1 O15075 1/20 0.79
ROCK2 O75116 1/20 0.79
CHEK2 O96017 1/20 0.79
GSK3A P49840 1/20 0.79
GSK3B P49841 1/20 0.79
IRAK1 P51617 1/20 0.79
PRKX P51817 1/20 0.79
NEK4 P51957 1/20 0.79
PLK1 P53350 1/20 0.79
CSNK1G2 P78368 1/20 0.79
CDC42BPA Q5VT25 1/20 0.79
BRSK1 Q8TDC3 1/20 0.79
CLK4 Q9HAZ1 1/20 0.79
STK17A Q9UEE5 1/20 0.79
CSNK1G3 Q9Y6M4 1/20 0.79
CYP3A4 P08684 1/20 0.79
CYP2D6 P10635 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4363945 0.92 MAPKAPK2 (0.77) MAPKAPK2ROCK1AURKBDCLK1ROCK2
SCHEMBL4366551 0.91 MAPKAPK2 (0.68) MAPKAPK2ROCK1AURKBDCLK1ROCK2
SCHEMBL4368763 0.90 MAPKAPK2 (0.69) MAPKAPK2ROCK1AURKBDCLK1ROCK2
SCHEMBL4378173 0.89 MAPKAPK2 (0.85) MAPKAPK2ROCK1AURKBDCLK1ROCK2
SCHEMBL4368075 0.88 MAPKAPK2 (1.00) MAPKAPK2ROCK1AURKBDCLK1ROCK2
SCHEMBL4364169 0.88 MAPKAPK2 (1.00) MAPKAPK2ROCK1AURKBDCLK1ROCK2
SCHEMBL4365652 0.88 MAPKAPK2 (1.00) MAPKAPK2ROCK1AURKBDCLK1ROCK2
SCHEMBL4370772 0.88 MAPKAPK2 (0.67) MAPKAPK2ROCK1AURKBDCLK1ROCK2
SCHEMBL4362293 0.88 MAPKAPK2 (0.68) MAPKAPK2ROCK1AURKBDCLK1ROCK2
SCHEMBL4366869 0.88 MAPKAPK2 (0.70) MAPKAPK2ROCK1AURKBDCLK1ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009012375-A2 SQUARATE KINASE INHIBITORS WYETH (US) 2009-01-22 WO claimed
WO-2009012375-A2 SQUARATE KINASE INHIBITORS WYETH (US) 2009-01-22 WO disclosed