Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 18/20 | 0.63 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367029 | 1.00 | HRH4 (0.63) | HRH4NUDT1HRH3 | |
| SCHEMBL2580475 | 0.85 | HRH4 (0.47) | HRH4NUDT1 | |
| SCHEMBL2580470 | 0.85 | HRH4 (0.47) | HRH4NUDT1 | |
| SCHEMBL601898 | 0.81 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL601899 | 0.81 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL603620 | 0.78 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL603621 | 0.78 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL604298 | 0.70 | HRH4 (0.53) | HRH4 | |
| SCHEMBL14997072 | 0.70 | HRH4 (0.52) | HRH4NUDT1 | |
| SCHEMBL606008 | 0.70 | HRH4 (0.52) | HRH4NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124560-A1 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2009-12-02 | — | — | EP | claimed |
| WO-2008100565-A1 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | claimed |