Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 15/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.38 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223818 | 0.90 | HDAC1 (0.44) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4232555 | 0.86 | HDAC1 (0.49) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4365544 | 0.82 | HDAC1 (0.47) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4234988 | 0.81 | HDAC1 (0.51) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4225220 | 0.78 | HDAC1 (0.45) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL2384770 | 0.77 | UTS2R (0.54) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4224033 | 0.77 | HDAC1 (0.51) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL3229763 | 0.77 | HDAC1 (0.47) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4229434 | 0.77 | UTS2R (0.55) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4229378 | 0.77 | HDAC1 (0.48) | HDAC1HDAC3HDAC8HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | claimed |
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |