Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.60 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.53 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15613351 | 0.90 | HSP90AB1 (0.67) | HSP90AB1HSP90AA1OPRM1HSP90B1TRAP1 | |
| SCHEMBL1220438 | 0.88 | HSP90AB1 (0.65) | HSP90AB1HSP90AA1OPRM1HSP90B1TRAP1 | |
| SCHEMBL1220268 | 0.87 | HSP90AB1 (0.64) | HSP90AB1HSP90AA1OPRM1HSP90B1TRAP1 | |
| SCHEMBL15613466 | 0.86 | HSP90AB1 (0.74) | HSP90AB1HSP90AA1OPRM1HSP90B1TRAP1 | |
| SCHEMBL16883493 | 0.86 | HSP90AB1 (0.63) | HSP90AB1HSP90AA1OPRM1HSP90B1TRAP1 | |
| SCHEMBL8130698 | 0.85 | HSP90AB1 (0.71) | HSP90AB1HSP90AA1OPRM1HSP90B1TRAP1 | |
| SCHEMBL19757268 | 0.85 | HSP90AB1 (0.62) | HSP90AB1HSP90AA1OPRM1HSP90B1TRAP1 | |
| SCHEMBL1220650 | 0.85 | HSP90AA1 (0.93) | HSP90AB1HSP90AA1OPRM1HSP90B1TRAP1 | |
| SCHEMBL14293452 | 0.85 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1OPRM1OPRK1OPRD1 | |
| SCHEMBL20878988 | 0.85 | HSP90AB1 (0.62) | HSP90AB1HSP90AA1OPRM1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354365-A1 | COMPOUNDS AND METHODS FOR TARGETING HSP90 | DUKE UNIVERSITY (US) | 2020-11-12 | — | — | US | disclosed |
| EP-2879675-B1 | COMPOUNDS AND METHODS FOR TARGETING HSP90 | UNIV DUKE (US) | 2019-11-13 | — | — | EP | disclosed |
| WO-2009114470-A2 | TETRAHYDROINDOLE AND TETRAHDYROINDAZOLE AS HSP90 INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-09-17 | — | — | WO | disclosed |
| WO-2009114470-A2 | TETRAHYDROINDOLE AND TETRAHDYROINDAZOLE AS HSP90 INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354365-A1 | COMPOUNDS AND METHODS FOR TARGETING HSP90 | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AB1 2/4885HSP90AA1 4/4885OPRM1 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.