Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 3/20 | 0.58 |
| ▸ | FES | P07332 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.48 |
| ▸ | GSK3A | P49840 | 8/20 | 0.48 |
| ▸ | GSK3B | P49841 | 8/20 | 0.48 |
| ▸ | CDC42BPA | Q5VT25 | 8/20 | 0.48 |
| ▸ | CSNK1G3 | Q9Y6M4 | 8/20 | 0.48 |
| ▸ | PRKACA | P17612 | 7/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 7/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 7/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 6/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369771 | 0.87 | FLT4 (0.52) | FLT4FESFGFR1KDRCYP17A1 | |
| SCHEMBL4364802 | 0.87 | FLT4 (0.58) | FLT4FESFGFR1KDRROCK1 | |
| SCHEMBL4378176 | 0.84 | FLT4 (0.76) | FLT4FESFGFR1KDRROCK1 | |
| SCHEMBL4376009 | 0.82 | FLT4 (0.71) | FLT4FESFGFR1KDRROCK1 | |
| SCHEMBL4365519 | 0.79 | FLT4 (0.58) | FLT4FESFGFR1KDRROCK1 | |
| SCHEMBL4374223 | 0.79 | FLT4 (0.67) | FLT4FESFGFR1KDRROCK1 | |
| SCHEMBL4369721 | 0.79 | GSK3A (0.75) | FLT4FESFGFR1KDRROCK1 | |
| SCHEMBL4364003 | 0.79 | FLT4 (0.67) | FLT4FESFGFR1KDRROCK1 | |
| SCHEMBL4366760 | 0.79 | FLT4 (0.67) | FLT4FESFGFR1KDRROCK1 | |
| SCHEMBL4366261 | 0.79 | ROCK1 (0.75) | FLT4FESFGFR1KDRROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | claimed |
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |