SCHEMBL4368299

SCHEMBL4368299

ONC(=Nc1ccc(F)c(C(F)(F)F)c1)c1nonc1[AsH2]

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 20/20 0.66
TDO2 P48775 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2517466 0.86 IDO1 (0.72) IDO1TDO2
SCHEMBL20585354 0.79 IDO1 (1.00) IDO1
SCHEMBL4368291 0.77 GRM4 (0.44) IDO1
SCHEMBL4368296 0.77 GRM4 (0.44) IDO1
SCHEMBL145346 0.77 IDO1 (0.77) IDO1TDO2
SCHEMBL146993 0.76 IDO1 (0.75) IDO1TDO2
SCHEMBL20585220 0.76 IDO1 (1.00) IDO1
SCHEMBL20585232 0.76 IDO1 (1.00) IDO1
SCHEMBL144291 0.75 IDO1 (0.78) IDO1TDO2
SCHEMBL144774 0.75 IDO1 (0.78) IDO1TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879573-A4 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME INCYTE CORP (US) 2009-07-08 EP claimed
EP-1879573-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME Incyte Corporation (US) 2008-01-23 EP claimed
WO-2006122150-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME INCYTE CORPORATION (US) 2006-11-16 WO claimed