Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13527138 | 0.86 | KCNH2 (0.44) | CYP8B1KCNH2SLC2A1 | |
| SCHEMBL1224389 | 0.85 | CYP8B1 (0.47) | CYP8B1KCNH2 | |
| SCHEMBL1224386 | 0.85 | CYP8B1 (0.47) | CYP8B1KCNH2 | |
| SCHEMBL14441508 | 0.84 | CYP8B1 (0.44) | CYP8B1KCNH2SLC2A1 | |
| SCHEMBL3665601 | 0.84 | CYP8B1 (0.46) | CYP8B1KCNH2ACVR1 | |
| SCHEMBL1224385 | 0.84 | CYP8B1 (0.46) | CYP8B1KCNH2ACVR1 | |
| SCHEMBL3179377 | 0.84 | CYP8B1 (0.46) | CYP8B1KCNH2ACVR1 | |
| SCHEMBL3259301 | 0.81 | MAP4K4 (0.44) | CYP8B1KCNH2SLC2A1 | |
| SCHEMBL1222880 | 0.80 | CYP8B1 (0.48) | CYP8B1 | |
| SCHEMBL4070886 | 0.80 | CYP8B1 (0.45) | CYP8B1KCNH2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773343-A4 | ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2009-05-13 | — | — | EP | disclosed |
| EP-1773343-A1 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006017326-A1 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |