Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.41 |
| ▸ | UBE2M | P61081 | 3/20 | 0.41 |
| ▸ | CDK14 | O94921 | 4/20 | 0.40 |
| ▸ | CCNY | Q8ND76 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 3/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1073443 | 0.96 | ALK (0.51) | ALKDCUN1D1UBE2MDRD4SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL1076552 | 0.90 | ALK (0.48) | ALKCDK14CCNY | |
| Trifluoroacetic Acid SCHEMBL4358301 | 0.89 | ALK (0.54) | ALK | |
| Trifluoroacetic Acid SCHEMBL4361604 | 0.89 | ALK (0.50) | ALK | |
| Trifluoroacetic Acid SCHEMBL4360830 | 0.89 | ALK (0.50) | ALK | |
| Trifluoroacetic Acid SCHEMBL4358088 | 0.88 | ALK (0.51) | ALK | |
| Trifluoroacetic Acid SCHEMBL4358255 | 0.88 | ALK (0.47) | ALKCDK14CCNY | |
| Trifluoroacetic Acid SCHEMBL4364663 | 0.88 | ALK (0.47) | ALKCDK14CCNY | |
| Trifluoroacetic Acid SCHEMBL4356671 | 0.88 | ALK (0.48) | ALKCDK14CCNY | |
| Trifluoroacetic Acid SCHEMBL4364370 | 0.88 | ALK (0.49) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | ALK 3/4885DCUN1D1 2819/4885UBE2M 2453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.