Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | AR | P10275 | 5/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | MATK | P42679 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | NEK4 | P51957 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368135 | 0.85 | POLB (0.52) | POLBMAPTGAAMAPKAPK2MEN1 | |
| SCHEMBL4023021 | 0.81 | POLB (0.64) | POLBMAPTGAAMAPKAPK2LMNA | |
| SCHEMBL7571735 | 0.79 | POLB (0.55) | POLBMAPTGAAMEN1KMT2A | |
| SCHEMBL10112748 | 0.78 | POLB (0.68) | POLBMAPTGAAMEN1KMT2A | |
| SCHEMBL7572017 | 0.76 | POLB (0.55) | POLBMAPTGAAPTK6MEN1 | |
| SCHEMBL8995732 | 0.75 | POLB (0.50) | POLBMAPTGAAMEN1KMT2A | |
| SCHEMBL6549773 | 0.74 | POLB (0.68) | POLBMAPTGAAMEN1KMT2A | |
| SCHEMBL7093309 | 0.73 | POLB (0.55) | POLBMAPTGAAMAPKAPK2MEN1 | |
| SCHEMBL4023982 | 0.73 | POLB (0.55) | POLBMAPTGAAKMT2ALMNA | |
| SCHEMBL7916278 | 0.73 | POLB (0.70) | POLBMAPTGAACHEK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |