Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 7/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025790 | 0.74 | GAA (0.57) | MAPTGAAPOLBALDH1A1LMNA | |
| SCHEMBL6986797 | 0.71 | TSHR (0.48) | MAPTGAAPOLBALDH1A1MEN1 | |
| SCHEMBL4366566 | 0.70 | GAA (0.49) | MAPTGAAPOLBHTT | |
| SCHEMBL30353174 | 0.69 | MEN1 (0.41) | GAAALDH1A1LMNAMPIAURKA | |
| SCHEMBL30353140 | 0.69 | MEN1 (0.40) | GAAALDH1A1LMNAMPIAURKA | |
| SCHEMBL4374914 | 0.69 | POLB (0.48) | MAPTGAAPOLBALDH1A1MEN1 | |
| SCHEMBL7916278 | 0.68 | POLB (0.70) | MAPTGAAPOLBALDH1A1AURKB | |
| SCHEMBL18154760 | 0.68 | ITK (0.56) | GAAALDH1A1LMNAMPIAURKA | |
| SCHEMBL4023021 | 0.67 | POLB (0.64) | MAPTGAAPOLBLMNAAURKB | |
| SCHEMBL1488204 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |