Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA4 | P22748 | 4/20 | 0.42 |
| ▸ | CA7 | P43166 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379865 | 0.89 | GAA (0.44) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4374520 | 0.89 | CA12 (0.43) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4370313 | 0.89 | FLT1 (0.43) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4370237 | 0.88 | KMT2A (0.43) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4370325 | 0.85 | FLT1 (0.56) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4380239 | 0.85 | CA12 (0.46) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4370393 | 0.85 | CA12 (0.42) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4371955 | 0.83 | FLT1 (0.41) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4371409 | 0.82 | CA12 (0.43) | CA12CA1CA2CA4CA7 | |
| SCHEMBL1884480 | 0.81 | TSHR (0.46) | POLBADRA1AALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625896-B2 | Pyridylsulfonamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-12-01 | — | — | US | claimed |