Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | CDK14 | O94921 | 2/20 | 0.36 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | STK4 | Q13043 | 1/20 | 0.35 |
| ▸ | STK3 | Q13188 | 1/20 | 0.35 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.35 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4360613 | 0.96 | ALK (0.48) | ALKEPHX2PTK2PTK2BJAK2 | |
| Trifluoroacetic Acid SCHEMBL4361347 | 0.96 | ALK (0.48) | ALKEPHX2PTK2PTK2BJAK2 | |
| SCHEMBL4365429 | 0.95 | ALK (0.54) | ALKEPHX2JAK2JAK3MAPT | |
| Trifluoroacetic Acid SCHEMBL1075844 | 0.94 | ALK (0.48) | ALKJAK2JAK3CDK14CCNY | |
| Trifluoroacetic Acid SCHEMBL1074515 | 0.91 | ALK (0.47) | ALKJAK2JAK3CDK14CCNY | |
| SCHEMBL1075130 | 0.91 | ALK (0.53) | ALKJAK2JAK3STK4STK3 | |
| SCHEMBL4361690 | 0.91 | ALK (0.53) | ALKJAK2JAK3STK4STK3 | |
| Trifluoroacetic Acid SCHEMBL4358088 | 0.91 | ALK (0.51) | ALKJAK2JAK3STK4STK3 | |
| Trifluoroacetic Acid SCHEMBL4358301 | 0.89 | ALK (0.54) | ALKPTK2JAK2JAK3STK4 | |
| SCHEMBL1075992 | 0.89 | ALK (0.53) | ALKJAK2JAK3MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | ALK 3/4885EPHX2 4177/4885PTK2 527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.