Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 19/20 | 0.90 |
| ▸ | PLG | P00747 | 15/20 | 0.84 |
| ▸ | F10 | P00742 | 7/20 | 0.84 |
| ▸ | F2 | P00734 | 6/20 | 0.84 |
| ▸ | ST14 | Q9Y5Y6 | 6/20 | 0.84 |
| ▸ | PLAT | P00750 | 4/20 | 0.84 |
| ▸ | HPN | P05981 | 2/20 | 0.84 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.84 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.84 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Upamostat SCHEMBL20669283 | 0.95 | PLAU (1.00) | PLAUPLGF10F2ST14 | |
| Upamostat SCHEMBL29376462 | 0.95 | PLAU (1.00) | PLAUPLGF10F2ST14 | |
| Upamostat SCHEMBL31331918 | 0.95 | PLAU (1.00) | PLAUPLGF10F2ST14 | |
| Upamostat SCHEMBL437037 | 0.95 | PLAU (1.00) | PLAUPLGF10F2ST14 | |
| Upamostat SCHEMBL23548883 | 0.93 | PLAU (0.97) | PLAUPLGF10F2ST14 | |
| Upamostat SCHEMBL30085342 | 0.93 | PLAU (0.97) | PLAUPLGF10F2ST14 | |
| Upamostat SCHEMBL30343420 | 0.93 | PLAU (0.97) | PLAUPLGF10F2ST14 | |
| Upamostat SCHEMBL23548880 | 0.93 | PLAU (0.96) | PLAUPLGF10F2ST14 | |
| SCHEMBL20675070 | 0.91 | PLAU (1.00) | PLAUPLGF10F2ST14 | |
| SCHEMBL30343433 | 0.91 | PLAU (1.00) | PLAUPLGF10F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46424-E1 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2017-06-06 | — | — | US | disclosed |
| US-RE46424-E1 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2017-06-06 | — | — | US | disclosed |
| US-8642761-B2 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2014-02-04 | — | — | US | disclosed |
| US-8642761-B2 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2014-02-04 | — | — | US | disclosed |
| US-20120065398-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | WILEX AG (DE) | 2012-03-15 | — | — | US | disclosed |
| US-20120065398-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | WILEX AG (DE) | 2012-03-15 | — | — | US | disclosed |
| US-8088921-B2 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2012-01-03 | — | — | US | disclosed |
| US-8088921-B2 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2012-01-03 | — | — | US | disclosed |
| US-20110087025-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | WILEX AG (DE) | 2011-04-14 | — | — | US | disclosed |
| US-20110087025-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | WILEX AG (DE) | 2011-04-14 | — | — | US | disclosed |
| US-7884206-B2 | N-alpha-2,4,6-triisopropylphenylsulfonyl-3-cyano-(L)-phenylalanine-4-ethoxycarbonyl piperazide dissolved in ethanol, mixed with hydroxylamine hydrochloride to produce N- alpha -2,4,6-Triisopropylphenylsulfonyl-3-amidino-(L)-phenylalanine-4-ethoxycarbonyl piperazide hydrochloride, reduction with H2, Pd/C | WILEX AG (DE) | 2011-02-08 | — | — | US | disclosed |
| US-7884206-B2 | N-alpha-2,4,6-triisopropylphenylsulfonyl-3-cyano-(L)-phenylalanine-4-ethoxycarbonyl piperazide dissolved in ethanol, mixed with hydroxylamine hydrochloride to produce N- alpha -2,4,6-Triisopropylphenylsulfonyl-3-amidino-(L)-phenylalanine-4-ethoxycarbonyl piperazide hydrochloride, reduction with H2, Pd/C | WILEX AG (DE) | 2011-02-08 | — | — | US | disclosed |
| US-20070123706-A1 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG | 2007-05-31 | — | — | US | disclosed |
| US-20070123706-A1 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG | 2007-05-31 | — | — | US | disclosed |
| US-7211670-B2 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2007-05-01 | — | — | US | disclosed |
| US-7211670-B2 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2007-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123706-A1 | Method for producing 3-amidinophenylalanine derivatives | APEH, PAH, DAO | PLAU 53/4885PLG 101/4885F10 422/4885 |
| US-20110087025-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | PAH, APEH, DAO | PLAU 63/4885PLG 109/4885F10 403/4885 |
| US-20120065398-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | PAH, APEH, DAO | PLAU 63/4885PLG 109/4885F10 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.