Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.58 |
| ▸ | PEPD | P12955 | 4/20 | 0.49 |
| ▸ | XPNPEP1 | Q9NQW7 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 4/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6738391 | 1.00 | DPP4 (0.58) | DPP4PEPDXPNPEP1POLBDPP8 | |
| SCHEMBL13673006 | 0.87 | BIRC2 (0.49) | DPP4PEPDXPNPEP1POLBDPP8 | |
| SCHEMBL22811047 | 0.86 | PEPD (0.47) | DPP4PEPDXPNPEP1POLBDPP8 | |
| SCHEMBL12599485 | 0.86 | CYP3A4 (0.49) | DPP4PEPDXPNPEP1POLBDPP8 | |
| SCHEMBL30534327 | 0.85 | DPP4 (0.61) | DPP4PEPDACERENKDM4E | |
| SCHEMBL17305538 | 0.85 | DPP4 (0.61) | DPP4PEPDACERENKDM4E | |
| SCHEMBL6978337 | 0.85 | DPP4 (0.61) | DPP4PEPDACERENKDM4E | |
| SCHEMBL17020372 | 0.85 | DPP4 (0.61) | DPP4PEPDDPP8DPP9ACE | |
| SCHEMBL8363726 | 0.83 | DPP4 (0.53) | DPP4PEPDDPP8DPP9ACE | |
| SCHEMBL17037452 | 0.83 | PEPD (0.52) | PEPDXPNPEP1POLBFKBP1AACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626023-B2 | Compounds for treating tumors | WYETH (US) | 2009-12-01 | — | — | US | disclosed |
| US-20080221181-A1 | COMPOUNDS FOR TREATING TUMORS | WYETH HOLDINGS CORPORATION (US) | 2008-09-11 | — | — | US | disclosed |
| US-7390910-B2 | Compounds for treating tumors | WYETH (US) | 2008-06-24 | — | — | US | disclosed |
| WO-2005016958-A2 | COMPOUNDS FOR TREATING TUMORS | WYETH HOLDINGS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| US-20050037977-A1 | Compounds for treating tumors | WYETH HOLDINGS CORPORATION (US) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221181-A1 | COMPOUNDS FOR TREATING TUMORS | RB1, MRPL9, BCOR | DPP4 4533/4885PEPD 4783/4885XPNPEP1 3358/4885 |
| US-20050037977-A1 | Compounds for treating tumors | RB1, MRPL9, BCOR | DPP4 4533/4885PEPD 4783/4885XPNPEP1 3358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.