Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.60 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.60 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27196733 | 0.91 | HSP90AB1 (0.61) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL13740696 | 0.90 | HSP90AB1 (0.65) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL30839279 | 0.90 | HSP90AB1 (0.74) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3631667 | 0.90 | HSP90AB1 (0.65) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL1220779 | 0.90 | HSP90AB1 (0.60) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL3633252 | 0.87 | HSP90AB1 (0.59) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL1747106 | 0.85 | HSP90AA1 (0.84) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL4380174 | 0.84 | HSP90AB1 (0.58) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL13740369 | 0.84 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL13740368 | 0.84 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009114470-A2 | TETRAHYDROINDOLE AND TETRAHDYROINDAZOLE AS HSP90 INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-09-17 | — | — | WO | disclosed |