Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.55 |
| ▸ | RAF1 | P04049 | 12/20 | 0.55 |
| ▸ | CSF1R | P07333 | 6/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363851 | 0.89 | BRAF (0.57) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL14396821 | 0.88 | BRAF (0.54) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2675728 | 0.88 | BRAF (0.55) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2676396 | 0.88 | BRAF (0.55) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2675735 | 0.88 | BRAF (0.55) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2677525 | 0.84 | BRAF (0.60) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2677608 | 0.83 | BRAF (0.61) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2676048 | 0.83 | BRAF (0.58) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2676704 | 0.83 | BRAF (0.58) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2676045 | 0.83 | BRAF (0.58) | BRAFRAF1CSF1RPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553854-B2 | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-06-30 | — | — | US | claimed |