Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 2/20 | 0.67 |
| ▸ | CSNK2A2 | P19784 | 6/20 | 0.64 |
| ▸ | CSNK2B | P67870 | 6/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.64 |
| ▸ | CSNK2A3 | Q8NEV1 | 6/20 | 0.64 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 6/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 6/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10093411 | 1.00 | CDC25B (0.67) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL496829 | 0.88 | DYRK1A (0.67) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL496943 | 0.88 | DYRK1A (0.67) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL10093420 | 0.84 | CDC25B (0.81) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL4379157 | 0.84 | CDC25B (0.81) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL497117 | 0.84 | CDC25B (0.81) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL497258 | 0.83 | KMT2A (0.66) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL497260 | 0.83 | KMT2A (0.66) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL497128 | 0.82 | DYRK1A (0.71) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL496852 | 0.82 | DYRK1A (0.71) | CDC25BCSNK2A2CSNK2BCSNK2A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648452-B1 | 2-IMINO-4-(THIO)OXO-5-POLYCYCLOVINYLAZOLINES FOR USE AS PI3 KINASE INHIBITORS | MERCK SERONO SA (CH) | 2009-07-22 | — | — | EP | claimed |