Flazalone

Flazalone

SCHEMBL43716

CN1CCC(O)(c2ccc(F)cc2)C(C(=O)c2ccc(F)cc2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 1.00
SLC6A3 Q01959 4/20 1.00
ALDH1A1 P00352 4/20 0.77
MAPT P10636 3/20 0.77
LMNA P02545 3/20 0.77
MEN1 O00255 1/20 0.47
MAPK1 P28482 1/20 0.47
OPRM1 P35372 1/20 0.41
DRD2 P14416 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7001985 0.88 KMT2A (0.79) KMT2ASLC6A3ALDH1A1MAPTLMNA
SCHEMBL6998081 0.87 KMT2A (0.77) KMT2ASLC6A3ALDH1A1MAPTLMNA
SCHEMBL7003749 0.87 KMT2A (0.77) KMT2ASLC6A3ALDH1A1MAPTLMNA
SCHEMBL6997233 0.87 KMT2A (1.00) KMT2ASLC6A3ALDH1A1MAPTLMNA
SCHEMBL7001736 0.85 KMT2A (0.73) KMT2ASLC6A3ALDH1A1MAPTLMNA
SCHEMBL7001075 0.84 KMT2A (0.72) KMT2ASLC6A3ALDH1A1MAPTLMNA
SCHEMBL7004017 0.84 KMT2A (1.00) KMT2ASLC6A3ALDH1A1MAPTLMNA
SCHEMBL14081616 0.84 KMT2A (0.72) KMT2ASLC6A3ALDH1A1MAPTLMNA
SCHEMBL7001626 0.83 KMT2A (0.70) KMT2ASLC6A3ALDH1A1MAPTLMNA
SCHEMBL10107795 0.80 KMT2A (0.66) KMT2ASLC6A3ALDH1A1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2796 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4335413-A2 PROSTHETIC TISSUE VALVES Cormatrix Cardiovascular, Inc. (US) 2024-03-13 EP claimed
WO-2023212179-A2 THERAPEUTIC COMPOSITIONS FOR SKIN DISORDERS AND WOUND REPAIR UNIVERSITY OF MIAMI (US) 2023-11-02 WO claimed
CN-114568442-A Blend of a bio-stimulant based on folate impurity 10 and an agrochemical of interest UPL有限责任公司 2022-06-03 CN claimed
US-20220110979-A1 FIBROBLAST REGENERATIVE CELLS FIGENE, LLC 2022-04-14 US claimed
EP-3908297-A1 FIBROBLAST REGENERATIVE CELLS Figene, LLC (US) 2021-11-17 EP claimed
EP-3279663-B1 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES BRIGHAM & WOMENS HOSPITAL INC (US) 2021-07-28 EP claimed
WO-2020146874-A1 FIBROBLAST REGENERATIVE CELLS FIGENE, LLC (US) 2020-07-16 WO claimed
EP-3279663-A1 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES The Brigham and Women's Hospital, Inc. (US) 2018-02-07 EP claimed
EP-3274006-A1 VASCULAR CASTED PROSTHESES AND METHODS OF FORMING SAME FOR TREATING BIOLOGICAL TISSUE Cormatrix Cardiovascular, Inc. (US) 2018-01-31 EP claimed
US-20170281724-A9 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2017-10-05 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
US-20030152566-A1 Soluble CD40L (CD154) as a prognostic marker of atherosclerotic diseases THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2003-08-14 US claimed
WO-2003040691-A2 SOLUBLE CD40L(CD154) AS A PROGNOSTIC MARKER OF ATHEROSCLEROTIC DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2003-05-15 WO claimed
WO-2001015744-A9 SYSTEMIC INFLAMMATORY MARKERS AS DIAGNOSTIC TOOLS IN THE PREVENTION OF ATHEROSCLEROTIC DISEASES BRIGHAM & WOMENS HOSPITAL (US) 2002-09-26 WO claimed
EP-1212101-A1 SYSTEMIC INFLAMMATORY MARKERS AS DIAGNOSTIC TOOLS IN THE PREVENTION OF ATHEROSCLEROTIC DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2002-06-12 EP claimed
JP-2001525058-A 2001-12-04 JP claimed
WO-2001015744-A1 SYSTEMIC INFLAMMATORY MARKERS AS DIAGNOSTIC TOOLS IN THE PREVENTION OF ATHEROSCLEROTIC DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2001-03-08 WO claimed
EP-1003501-A4 MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE BRIGHAM & WOMENS HOSPITAL (US) 2001-01-17 EP claimed
EP-1003501-A1 MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2000-05-31 EP claimed
WO-1998043630-A1 MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 1998-10-08 WO claimed