Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.50 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374224 | 0.90 | AR (0.57) | ARMERTKSCN9AEGFRERBB2 | |
| SCHEMBL11649803 | 0.83 | SLC6A4 (0.57) | ARMERTKEGFRERBB2ERBB3 | |
| SCHEMBL4368827 | 0.83 | AR (0.58) | ARMERTKSCN9AERBB2SLC6A4 | |
| SCHEMBL8545187 | 0.81 | MERTK (0.55) | ARMERTKSCN9AEGFRERBB2 | |
| SCHEMBL2788214 | 0.81 | AR (0.55) | ARMERTKSCN9AEGFRERBB2 | |
| SCHEMBL11424391 | 0.81 | MERTK (0.49) | ARMERTKSCN9AEGFRERBB2 | |
| SCHEMBL921021 | 0.80 | FFAR1 (0.54) | ARMERTKSLC6A4HTR2AKCNH2 | |
| SCHEMBL5897452 | 0.80 | SLC6A4 (0.54) | ARMERTKSLC6A4 | |
| SCHEMBL4188121 | 0.79 | AR (0.60) | ARSLC6A4KCNH2FFAR1SLC6A2 | |
| SCHEMBL31264488 | 0.78 | PDE7A (0.56) | SCN9ASLC6A4HTR2AKCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |