Busulfan

Busulfan

SCHEMBL4373

CS(=O)(=O)OCCCCOS(C)(=O)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 1.00
USP2 O75604 2/20 1.00
KDM4E B2RXH2 1/20 1.00
ALDH1A1 P00352 1/20 1.00
LMNA P02545 1/20 1.00
MMP9 P14780 1/20 1.00
ALOX15 P16050 1/20 1.00
CA1 P00915 16/20 0.50
CA2 P00918 16/20 0.50
CA9 Q16790 15/20 0.50
CA12 O43570 5/20 0.48
CA7 P43166 5/20 0.48
CA14 Q9ULX7 5/20 0.48
CA3 P07451 4/20 0.48
CA4 P22748 4/20 0.48
CA6 P23280 4/20 0.48
CA5A P35218 4/20 0.48
CA5B Q9Y2D0 4/20 0.48
RECQL P46063 2/20 0.42
GLA P06280 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Busulfan SCHEMBL4764696 1.00 TSHR (1.00) TSHRUSP2KDM4EALDH1A1LMNA
SCHEMBL1931795 0.97 TSHR (0.94) TSHRUSP2KDM4EALDH1A1LMNA
SCHEMBL1335477 0.97 TSHR (0.94) TSHRUSP2KDM4EALDH1A1LMNA
Busulfan SCHEMBL29364030 0.97 TSHR (0.94) TSHRUSP2KDM4EALDH1A1LMNA
SCHEMBL8592211 0.97 TSHR (0.94) TSHRUSP2KDM4EALDH1A1LMNA
SCHEMBL4952202 0.97 TSHR (0.94) TSHRUSP2KDM4EALDH1A1LMNA
SCHEMBL4298840 0.97 TSHR (0.94) TSHRUSP2KDM4EALDH1A1LMNA
Busulfan SCHEMBL7195165 0.97 TSHR (0.94) TSHRUSP2KDM4EALDH1A1LMNA
SCHEMBL4954793 0.97 TSHR (0.94) TSHRUSP2KDM4EALDH1A1LMNA
Busulfan SCHEMBL29911485 0.97 TSHR (0.94) TSHRUSP2KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 169040 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144239-A1 Immune Cell-Engrafted Non-Human Animals and Non-Human Animal Models LAPIX THERAPEUTICS, INC. (US) 2026-05-28 US claimed
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
US-20260137685-A1 SOLID PHARMACEUTICAL FORMULATION OF PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS SHANGHAI INC (CN) 2026-05-21 US claimed
US-20260139071-A1 Subcutaneous Formulations Of Anti-CD38 Antibodies And Their Uses JANSSEN BIOTECH INC (US) 2026-05-21 US claimed
US-20260137686-A1 SOLID PHARMACEUTICAL FORMULATION OF PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS SHANGHAI INC (CN) 2026-05-21 US claimed
US-20260137650-A1 MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) 11949098 CANADA INC (CA) 2026-05-21 US claimed
WO-2026102563-A1 DISUBSTITUTED PYRIMIDOPYRROLE ANALOG AND USE THEREOF 深圳湾实验室坪山生物医药研发转化中心 2026-05-21 WO claimed
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
US-4851219-A ADMINISTERING GAMMA-INTERFERON GENENTECH, INC. (US) 1989-07-25 US claimed
WO-1989005346-A1 STIMULATION OF STEM CELL GROWTH BY THE BRYOSTATINS THE JOHNS HOPKINS UNIVERSITY (US) 1989-06-15 WO claimed
WO-1989002734-A1 VASOCONSTRICTIVE SUBSTANCES IN COMBINATION WITH CYTOTOXIC AGENTS MATRIX PHARMACEUTICALS, INC. (US) 1989-04-06 WO claimed
EP-0273754-A2 Method of enhancing the biodistribution of antibody for localization in lesions CITY OF HOPE NATIONAL MEDICAL CENTER (US) 1988-07-06 EP claimed
EP-0120907-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY Aston Molecules Limited (GB) 1984-10-10 EP claimed
WO-1984001506-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY UNIV BIRMINGHAM (GB) 1984-04-26 WO claimed
EP-0083600-A1 Use of alkaloid derivatives for the manufacture of a medicament for the strengthening of the immune system and for the treatment of viral, bacterial and fungal infections. NOWICKY WASSILI 1983-07-20 EP claimed
WO-1983000486-A1 METHOD FOR THE DIAGNOSTIC AND THE THERAPEUTIC TREATMENT OF TUMORS AND/OR INFECTIOUS DISEASES OF ALL SORTS BY THE USE OF ALKALOID COMPOSITIONS OR THE SALTS THEREOF NOWICKY, WASSYL 1983-02-17 WO claimed
EP-0010964-A1 Ravidomycin, process of preparation and pharmaceutical compositions containing same AYERST, MCKENNA AND HARRISON INC. (CA) 1980-05-14 EP claimed
US-4147767-A CROSSLINKED WITH FORMALDEHYDE OR GLUTARALDEHYDE MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1979-04-03 US claimed