Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16857372 | 0.89 | EGLN3 (0.48) | AKR1B1EGLN1EGLN3EGLN2HIF1A | |
| SCHEMBL4355029 | 0.88 | EGLN1 (0.47) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL4358358 | 0.88 | EGLN3 (0.45) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL4365361 | 0.86 | EGLN3 (0.42) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL4362443 | 0.85 | EGLN3 (0.52) | EGLN1EGLN3EGLN2PTGDR2 | |
| SCHEMBL4364439 | 0.85 | EGLN3 (0.46) | AKR1B1EGLN1EGLN3EGLN2PTGDR2 | |
| SCHEMBL4362515 | 0.85 | EGLN3 (0.41) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL29895408 | 0.84 | AKR1B1 (0.51) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL3852035 | 0.84 | AKR1B1 (0.51) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL29895409 | 0.84 | AKR1B1 (0.51) | AKR1B1MEN1CYP1A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |