Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLG | P54098 | 2/20 | 0.82 |
| ▸ | ALB | P02768 | 3/20 | 0.71 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Emtricitabine 5'-Triphosphate SCHEMBL14354587 | 0.90 | POLG (1.00) | POLGALBCACNA1FLMNAMAPT | |
| Emtricitabine 5'-Triphosphate SCHEMBL30480833 | 0.90 | POLG (1.00) | POLGALBCACNA1FLMNAMAPT | |
| Emtricitabine 5'-Triphosphate SCHEMBL606449 | 0.90 | POLG (1.00) | POLGALBCACNA1FLMNAMAPT | |
| Emtricitabine SCHEMBL2152774 | 0.86 | ALB (0.91) | POLGALBCACNA1FLMNAMAPT | |
| Emtricitabine SCHEMBL15532100 | 0.86 | ALB (0.91) | POLGALBCACNA1FLMNAMAPT | |
| SCHEMBL25520823 | 0.85 | ALB (0.73) | POLGALBCACNA1FLMNAMAPT | |
| SCHEMBL15788452 | 0.85 | ALB (0.73) | POLGALBCACNA1FLMNAMAPT | |
| SCHEMBL15788418 | 0.85 | ALB (0.73) | POLGALBCACNA1FLMNAMAPT | |
| SCHEMBL15259218 | 0.85 | ALB (0.73) | POLGALBCACNA1FLMNAMAPT | |
| Emtricitabine SCHEMBL39708 | 0.83 | ALB (1.00) | POLGALBCACNA1FLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155695-B1 | Use of a 1,3 oxathiolane nucleoside analogue in the manufacture of a medicament for specific administration | SHIRE CANADA INC (CA) | 2009-11-18 | — | — | EP | disclosed |
| EP-0526253-B1 | 1,3-Oxathiolane nucleoside analogues | SHIRE BIOCHEM INC (CA) | 2002-11-13 | — | — | EP | disclosed |
| EP-1155695-A1 | 1,3 oxathiolane nucleoside analogues | BIOCHEM PHARMA INC (CA) | 2001-11-21 | — | — | EP | disclosed |
| US-5618820-A | (-)CIS-4-AMINO-5-FLUORO-1-(2-HYDROXYMETHYL-1,3-OXATHIOLAN-5 YL-(1H)-PYRIMIDINE-2-ONE OR SALT OR ESTER; ADMINISTERING TO TREAT VIRAL INFECTION IN A MAMMAL | BIOCHEM PHARMA, INC. (CA) | 1997-04-08 | — | — | US | disclosed |
| US-5538975-A | (-)-4-AMINO-5-FLUORO-1-(2-HYDROXYMETHYL-1,3-OXATHIOLAN-5YL) -(1H)-PYRIMIDIN-2-ONE AND DERIVATIVES; ANTIVIRAL AGENT | BIOCHEM PHARMA, INC. (CA) | 1996-07-23 | — | — | US | disclosed |
| WO-1993003027-A1 | 1,3-OXATHIOLANE NUCLEOSIDE ANALOGUES | BIOCHEM PHARMA INC. (CA) | 1993-02-18 | — | — | WO | disclosed |
| EP-0526253-A1 | 1,3-Oxathiolane nucleoside analogues | BIOCHEM PHARMA INC. (CA) | 1993-02-03 | — | — | EP | disclosed |