SCHEMBL4374446

SCHEMBL4374446

Cn1c(N)nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)C2F)c1=O

nearest known ligand 0.63

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 6/20 0.63
ADORA3 P0DMS8 4/20 0.63
ADORA1 P30542 3/20 0.63
PDE2A O00408 1/20 0.63
ADRA1A P35348 1/20 0.63
PDE4D Q08499 1/20 0.63
PDE3A Q14432 1/20 0.63
CD99 P14209 1/20 0.54
LMNA P02545 1/20 0.53
NT5E P21589 1/20 0.53
HIF1A Q16665 1/20 0.53
CYP1A2 P05177 1/20 0.52
CYP2C19 P33261 1/20 0.51
ADORA2B P29275 3/20 0.50
SLC29A1 Q99808 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21385677 1.00 ADORA2A (0.63) ADORA2AADORA3ADORA1PDE2AADRA1A
SCHEMBL4540748 0.92 ADORA2A (0.53) ADORA2AADORA3ADORA1PDE2AADRA1A
SCHEMBL14929125 0.90 CYP2C19 (0.62) ADORA2AADORA3ADORA1LMNANT5E
SCHEMBL62505 0.90 CYP2C19 (0.62) ADORA2AADORA3ADORA1LMNANT5E
SCHEMBL18844803 0.90 CYP2C19 (0.62) ADORA2AADORA3ADORA1LMNANT5E
SCHEMBL343478 0.90 CYP2C19 (0.62) ADORA2AADORA3ADORA1LMNANT5E
SCHEMBL14931005 0.90 CYP2C19 (0.62) ADORA2AADORA3ADORA1LMNANT5E
SCHEMBL18512921 0.90 CYP2C19 (0.62) ADORA2AADORA3ADORA1LMNANT5E
SCHEMBL25101160 0.89 CYP2C19 (0.61) ADORA2AADORA3ADORA1LMNANT5E
SCHEMBL29388779 0.89 CYP2C19 (0.61) ADORA2AADORA3ADORA1LMNANT5E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2010659-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA Epicentre Technologies (US) 2009-01-07 EP claimed
WO-2007120863-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA EPICENTRE TECHNOLOGIES (US) 2007-10-25 WO claimed
US-9115380-B2 Kits and methods for generating 5′ capped RNA CELLSCRIPT, LLC (US) 2015-08-25 US disclosed
US-20150191760-A1 KITS AND METHODS FOR GENERATING 5' CAPPED RNA CELLSCRIPT LLC (US) 2015-07-09 US disclosed
US-9005930-B2 Kits and methods for generating 5′ capped RNA CELLSCRIPT, LLC (US) 2015-04-14 US disclosed
US-20140363876-A1 KITS AND METHODS FOR GENERATING 5' CAPPED RNA EPICENTRE TECHNOLOGIES 2014-12-11 US disclosed
US-8846348-B2 Kits and methods for generating 5′ capped RNA CELLSCRIPT, LLC (US) 2014-09-30 US disclosed
US-20140221248-A1 KITS AND METHODS FOR GENERATING 5' CAPPED RNA CELLSCRIPT, LLC (US) 2014-08-07 US disclosed
EP-2010659-B1 Kits and methods for generating 5' capped RNA CELLSCRIPT INC (US) 2014-06-18 EP disclosed
EP-2010659-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA Epicentre Technologies (US) 2009-01-07 EP disclosed
US-20070281336-A1 Kits and methods for generating 5' capped RNA EPICENTRE TECHNOLOGIES (US) 2007-12-06 US disclosed
WO-2007120863-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA EPICENTRE TECHNOLOGIES (US) 2007-10-25 WO disclosed