SCHEMBL4374908

SCHEMBL4374908

C[C@@H](Nc1c(N)c(=O)c1=O)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 8/20 0.55
AURKB Q96GD4 3/20 0.55
ROCK1 Q13464 2/20 0.55
CYP3A4 P08684 2/20 0.55
CYP2C9 P11712 2/20 0.55
PLK1 P53350 2/20 0.55
PDGFRA P16234 2/20 0.55
MAPK1 P28482 2/20 0.55
CSNK1G1 Q9HCP0 2/20 0.55
DCLK1 O15075 1/20 0.55
ROCK2 O75116 1/20 0.55
CHEK2 O96017 1/20 0.55
GSK3A P49840 1/20 0.55
GSK3B P49841 1/20 0.55
IRAK1 P51617 1/20 0.55
PRKX P51817 1/20 0.55
NEK4 P51957 1/20 0.55
CSNK1G2 P78368 1/20 0.55
CDC42BPA Q5VT25 1/20 0.55
BRSK1 Q8TDC3 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14081327 0.80 MAPKAPK2 (0.47) MAPKAPK2AURKBROCK1CYP3A4CYP2C9
SCHEMBL3717414 0.78 CXCR2 (0.52) MAPKAPK2HDAC1CXCR2CXCR1KDM4E
SCHEMBL3717416 0.78 CXCR2 (0.52) MAPKAPK2HDAC1CXCR2CXCR1KDM4E
SCHEMBL17920542 0.77 MAPKAPK2 (0.80) MAPKAPK2AURKBROCK1CYP3A4CYP2C9
SCHEMBL7787683 0.72 MAPKAPK2 (0.45) MAPKAPK2AURKBROCK1CYP3A4CYP2C9
SCHEMBL4368075 0.71 MAPKAPK2 (1.00) MAPKAPK2AURKBROCK1CYP3A4CYP2C9
SCHEMBL4365652 0.71 MAPKAPK2 (1.00) MAPKAPK2AURKBROCK1CYP3A4CYP2C9
SCHEMBL4364169 0.71 MAPKAPK2 (1.00) MAPKAPK2AURKBROCK1CYP3A4CYP2C9
SCHEMBL14451006 0.69 ELANE (0.47) MAPKAPK2AURKBROCK1CYP3A4CYP2C9
SCHEMBL6265543 0.69 ELANE (0.47) MAPKAPK2AURKBROCK1CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009012375-A2 SQUARATE KINASE INHIBITORS WYETH (US) 2009-01-22 WO disclosed